Dear all,

With great pleasure we announce that the 32nd annual meeting of the NVCB will be held on 10 & 11 November 2022 in “Conferentiecentrum Woudschoten te Zeist”.

Invited and confirmed Speakers:

Prof. Dr. Wim van Hul, Centrum Medische Genetica, Antwerp University, Belgium
Dr. Rachel Schats, Human Osteoarchaeology in the Faculty of Archaeology, Leiden University, the Netherlands
Prof. dr. Irene Mathijssen, Chirurg, afdeling Plastische en Reconstructieve Chirurgie, Erasmus MC, the Netherlands

Registration and abstract submission is now open here. The registration/submission deadline is 9th October 2022.
The final program will be published on the website of our society (www.nvcb.nl).
(In case the link doesn’t work go to: https://forms.gle/rdEJBL3gCGtm4SQy7)

If you want to submit an abstract, please make sure that your abstract is finished before continuing the registration process.

Guidelines Abstract:

Title: max 30 words

Abstract text: max 300 words

Title, Authors, Presenting Author & Abstract can be pasted into the registration form. There is no need to format the abstract (font styles/face/size)

Best Publication Award

In 2022 a prize will be awarded for the best publication in the field of bone and calcified tissue research, the “Best Publication Award” (€250) at the annual meeting. PhD students as well as those that have received their PhD not longer than two years ago can apply for this award. The scientific publication should be sent before 1st of October as a PDF-file to the secretary of the society (info@nvcb.nl). The manuscript must have been published between 1 July 2020 and 30 June 2022. More details can be found on the NVCB website.

Hope to see many of you!

Max Gijsbertsen has won the Curaphar best presentation award during the 2021 yearly meeting of the NVCB. He presented his research on the generation of a Crouzon Syndrome cell line using prime editing and characterization of craniosynostosis patient specific hiPSCs.

dr Maaike Schilperoort (LUMC/Colombia University) was presented with the Kyowa Kyrin best thesis award 2021 for her thesis: it’s about time.

The thesis targets various consequences of disruption of the internal biological clock, including the consequences on bone.  A consistent circadian rhythm is essential for long-term health, and chronic circadian disturbances have been strongly associated with cardiometabolic diseases and metabolic bone disturbances in humans.  This thesis provides insight into the role of circadian rhythm in the development of (cardio)metabolic diseases, and elucidates novel approaches to prevent diseases associated with circadian disturbances.  She discovered that strong rhythms in the expression of circadian clock genes within the bones of mice, were clearly disrupted by shifting light-dark cycles. Repeated shifts in light-dark cycle decreased plasma levels of markers for bone formation and resorption, indicative of a reduced bone turnover. Consistent with these observations,  abnormalities in trabecular bone structure and an increased cortical bone mineralization were found. Altogether, the bones of mice exposed to shifting light-dark cycles show an osteoporotic phenotype that may explain the increased incidence of bone fractures in shift workers.

Furthermore a disturbed glucocorticoid rhythm could also underlie the association between circadian disruption and osteoporosis. Experimental flattening of the corticosterone rhythm in mice tilted the balance in bone remodeling towards bone resorption, thereby reducing bone volume and density. The observed alterations in bone structure negatively affected the mechanical properties of bone, as reflected by a decreased bone strength and stiffness. Together, these results indicate that a disturbed glucocorticoid rhythm can indeed increase the risk of osteoporotic fractures. .This is not only relevant for shiftworkers, but also for patients that have a blunted endogenous glucocorticoid rhythm due to exogenous glucocorticoid administration. In these patients, well-designed chronotherapy with glucocorticoids may reduce osteoporotic adverse effects. The full thesis is available here. 

Dr. Maaike Schilperoort is currently working as a postdoctoral researcher at Colombia University, USA and therefore her award was collected by the supervisor of her bone experiments, dr Liesbeth Winter (LUMC).

Dr. Fernando Rivadeneira has been  appointed as professor of Translational Skeletal Genomics at the Erasmus MC- Faculty of Erasmus University Rotterdam. He will publicly accept his appointment on Friday 3 December 2021 with an inaugural lecture entitled: Embracing the randomness of collapse.

The ceremony will begin at 16.00 hrs promptly in the Aula, Erasmus building, of the university, Burgemeester Oudlaan 50, Rotterdam.

You can attend the inaugural lecture via livestream:

With great pleasure we announce that the 31th annual meeting of the NVCB will be held on 11 & 12 November 2021 in “Conferentiecentrum Woudschoten te Zeist”.

𝗜𝗻𝘃𝗶𝘁𝗲𝗱 𝗮𝗻𝗱 𝗰𝗼𝗻𝗳𝗶𝗿𝗺𝗲𝗱 𝘀𝗽𝗲𝗮𝗸𝗲𝗿:

Prof. Dr. Bente L. Langdahl, Aarhus University, Aarhus, Denmark
Dr. Bram van der Eerden, Erasmus MC, Rotterdam, the Netherlands
Dr. Alexandra Ertl , Medical University of Vienna, Austria.
Dr. Christa Maes, KU Leuven, Belgium

𝗦𝗽𝗲𝗰𝗶𝗮𝗹 𝗮𝗻𝗻𝗶𝘃𝗲𝗿𝘀𝗮𝗿𝘆 𝗹𝗲𝗰𝘁𝘂𝗿𝗲:

Andre Kuipers

Registration and abstract submission is now open here. The registration/submission deadline is 1st October 2021!

The final program will be published on the website of our society (www.nvcb.nl).

If you want to submit an abstract, please make sure that your abstract is finished before continuing the registration process at https://forms.gle/ps9MjxtB7yLTJdtj8.

We are looking forward to welcoming you at the NVCB meeting in November!

In het LUMC is de PAPS-studie (PAmidronate for Pain in Sternocostoclavicular Hyperostosis) van start gegaan. In deze studie wordt de werkzaamheid van pamidronaat dubbelblind vergeleken met placebo in Sternocostoclaviculaire Hyperostose (SCCH).

SCCH is een zeldzame botaandoening met een vooralsnog onbekende etiologie. De ziekte karakteriseert zich door een inflammatoir proces in het gebied van het sternum, de clavicula(e) en de ribben, waarbij door de inflammatie verhoogde botturnover plaatsvindt. Dit proces leidt uiteindelijk tot de kenmerkende hyperostose, en tevens op de lange termijn tot sclerose en mogelijk degeneratieve transformatie van het aangedane weefsel.

De PAPS-studie is open voor inclusie en er kan gericht verwezen worden naar het LUMC voor de duur van de studie, 12 maanden. Meer informatie over de studie voor patiënten is te vinden op www.scch.nl en op de website van het Centrum van Botkwaliteit van het LUMC.

Deze studie is mogelijk gemaakt door ReumaNederland en wordt uitgevoerd door dr. Liesbeth Winter(PI) en  dr.Natasha Appelman-Dijkstra en onderzoeker Anne Leerling. Bij vragen neem vooral contact op!

De NVCB is 30 jaar geworden en dat hebben we dit jaar digitaal gevierd. Helaas was een fysieke vergadering niet mogelijk maar dat mocht de ZOOM pret niet drukken. Diverse keynote speakers zoals Laurence Vico, Jack van Loon, Thomas Carpenter en Gabri van der Pluijm hebben zeer interessante presentaties gegeven en ook de ingestuurde abstracts waren weer van hoge kwaliteit. Deze najaarsvergadering was misschien wel de interactiefste ooit en heeft er in ieder geval voor gezorgd dat het bestuur kan gaan bijklussen als congresbureau. Toch hopen we jullie volgend jaar weer te zien op locatie om het glas te heffen. Tot 11 en 12 november 2021!

Ton Schoenmaker ontving vandaag de award voor beste Abstract. Ton’s abstract over Activin A en FOP werd verkozen als beste abstract van de digitale najaarsvergadering van de NVCB.

With great pleasure we announce that the 30th annual meeting of the NVCB will be held on 12 & 13 November 2020 in “Conferentiecentrum Woudschoten te Zeist”. We still have the intention to organise a physical meeting following all current guidelines of the RIVM. For those who cannot join but who really would like to attend we are trying to set up a livestream that will broadcast the annual meeting.

Some highlights of the Program:

– Hypergravity vs Microgravity: Prof. Dr. Laurence Vico, INSERM, St. Etienne, France & Dr. Ing. Jack van Loon, ACTA, Amsterdam
– Mineral homeostasis and the bone: Prof. Dr. Thomas Carpenter, Yale, USA
– Bone and Cancer: Prof. Dr. Gabri van der Pluijm, LUMC, Leiden

Registration and abstract submission is now open here. The registration/submission deadline is ??th October 2020!

We are looking forward to welcoming you at the NVCB meeting in November!

De nieuwsbrief van juli 2020 staat online, met onder andere de data van de najaarsvergadering.

Voor dat en meer: Link naar de nieuwsbrief (English)